With Williams being out for Round 1, are people still considering him for starting teams?
To me, I think it comes down to whether you're playing for overall or league. I usually just play for league, where the first round isn't a competitive matchup, and so it makes complete sense to still start with Williams as it will have no impact to your W-L record.
If you're playing for overall, it's a tough one week proposition to start him on the bench as the defensive rookie stocks are looking quite weak this season. If it goes badly, you could be starting off at a 60-70 point disadvantage right off the bat.
That's my two cents anyway...